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Author: Admin | 2025-04-28
(6) Ganciclovir (Cytovene)- mutagenic & teratogenic(7) Antineoplastics (methotrexate, cyclophosphamide)- mutagenic Also, remember not to use the counting machine to count these drugs. Reference: Pharmacist's Letter/Prescriber's Letter 2006;22(3):220339. Sorry - I don't agree with this broad statement. "Handling" doesn't imply not doing the dispensing. Women can & do dispense all of these drugs. Additionally, female partners of men who use finansteride continue to have sexual relationships which, in my experience, have been accepted by both the male's physician & the females's ob-gyn. Finansteride is found in seminal fluid. These pts are followed as well as their offspring. I, myself, am a DES child who has been followed for more than 40 years. For exposure, proper monitoring is the key. Fortunately, drug manufactuers have designed these drugs so manipulation by other than the person it is intended for is kept to a minimum (gel caps, unit dose packages of androgel, a 2 week or month's supply of 5-FU in one tube, etc....There are far more mutagenic drugs which you don't list here & those techs & pharmacists (both male & female) who mix antineoplastics in any large quantity (think MD Anderson, Mayo Clinic, UCSF, etc...) - all employees have routine urine teratogen testing which will go on for the duration of their lives. To date, there are few teratogenic or mutagenic diseases which has been documented by the "proper" compounding of antineoplastics - done in a vertical laminar flow hood. The ones that have been reported are not out of the statistical significance of the disease itself, however, I've not looked at the statistics in a long,long time. Many, many years ago, these were done on the counter of a med room or the doctor's office so those folks have never been followed. I've spent years compounding antineoplastics & am still offered urine monitoring as often as I choose.Just dispensing these drugs should not be cause for concern - which many technicians, who have little education about "handling" might misinterpret. Now, mixing a 5-FU in a lotion form might be better handled by someone of my age, however, I would still use proper handling techniques - double gloves & mask. But, unpacking a 5-FU tube, counting out Proscar or labeling a box of Androgel should not be cause for concern. In addition, the form of the drug itself is deliberately designed so those who dispense it (pharmacists & nurses) are not exposed
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