Comment
Author: Admin | 2025-04-28
Cells) and taken out of action. By preventing this, more serotonin is available to act on the brain. Which Is More Effective? In terms of effectiveness, Lexapro exerts greater action against a liver enzyme called CYP4D6 that breaks down serotonin so that it can be reabsorbed by the body. As such, it can be considered "superior" to Zoloft in its ability to prevent serotonin uptake. With that said, Lexapro tends to cause more intolerable side effects, limiting its use for certain conditions and in certain populations. Dosage Both Lexapro and Zoloft are taken by mouth once daily with or without food in the morning or evening. Both are started with a lower initial dose. If the desired effects are not achieved, the dose can be gradually increased up to the maximum daily dose Because of its increased efficacy in suppressing CYP4D6, Lexapro requires lower doses than Zoloft for approved treatments. ConditionLexaproZoloftMDDInitial dose: 10 mgMaximum dose: 20 mgInitial dose: 50 mgMaximum dose: 200 mgGADInitial dose: 10 mgMaximum dose: 20 mgNot applicableOCDInitial dose: 10 mgMaximum dose: 20 mgInitial dose: 25 to 50 mgMaximum dose: 200 mgPDNot applicableInitial dose: 25 mgMaximum dose: 200 mgPTSDNot applicableInitial dose: 25 mgMaximum dose: 200 mgSADNot applicableInitial dose: 25 mgMaximum dose: 200 mgPMDDNot applicableInitial dose: 50 mgMaximum dose: 100 mg Side Effects Comparatively, Zoloft causes side effects more frequently than Lexapro. For instance, while Lexapro causes nausea in 15% of users and diarrhea in 8% of users, Zoloft will cause the same in 26% and 20% of users, respectively. On the flip side, Lexapro is more likely to cause intolerable side effects. Clinical studies have shown that 6% of Lexapro users will stop treatment due to drug intolerability compared to only 2% to 3% of Zoloft users. This explains in part why Lexapro is approved for fewer mental
Add Comment