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Author: Admin | 2025-04-28
20–45 hours on average to get hydrocodone out of your system. How long hydrocodone stays in your system largely depends on the drug’s formulation, liver health, age, metabolic rate, the extent of your opioid use, and whether or not you’re taking any other medications besides hydrocodone. Hydrocodone is eliminated from the body through urine. Before excretion, it is metabolized in the liver into two metabolites—hydromorphone and norhydrocodone. After taking hydrocodone, you will feel pain relief, as it hinders the transmission of pain signals between the body and the brain. Moreover, you may feel euphoric and relaxed. Some people also experience various hydrocodone side effects, such as difficulty breathing and constipation. To minimize the risk of side effects, take hydrocodone strictly as instructed by a doctor. Hydrocodone effects last between 4 and 24 hours, which primarily depends on the drug’s formulation and dosage. Immediate-release hydrocodone may provide pain relief for around four hours, whereas the duration of action of extended-release hydrocodone is typically 12 or 24 hours. Hydrocodone is very addictive, as it gradually alters the brain, causing it to produce more opioid receptors and hindering the production of endorphins. Though taking it as prescribed reduces the risk of addiction, even those who follow their doctor’s instructions to a T can fall prey to opioid use disorder (OUD). Hydrocodone is not stronger than oxycodone; both hydrocodone and oxycodone are highly potent, and they have similar pain-relieving effects.A study conducted by Catherine Marco et al. found that there was no difference in
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