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Author: Admin | 2025-04-28
HomeMestinonSide Effects Generic name: pyridostigmineMedically reviewed by Drugs.com. Last updated on May 8, 2024. Professional infoFAQ Note: This document provides detailed information about Mestinon Side Effects associated with pyridostigmine. Some dosage forms listed on this page may not apply specifically to the brand name Mestinon.Applies to pyridostigmine: oral conventional 30-mg tablets for military use, oral conventional 60-mg tablets and extended-release tablets, oral oral solution, parenteral injection. Military Use for Soman Poisoning ProphylaxisUse of pyridostigmine alone is not protective against soman effects.111 Efficacy depends on rapid use of nerve agent antidotes (i.e., atropine and pralidoxime) following nerve agent exposure.111Protective garments (e.g., masks, hoods, overgarments) specifically designed for protection from chemical nerve agents are the primary means of protection against nerve agent exposure; do not rely solely on pretreatment with pyridostigmine, atropine, and pralidoxime to provide complete protection.111Do not administer pyridostigmine after soman exposure.111 Discontinue at first sign of nerve agent poisoning; may exacerbate effects of a sublethal exposure.111Experience of Health Care PersonnelPyridostigmine should be administered by IV injection only by adequately trained individuals familiar with the drug’s actions, characteristics, and risks.124 Side effects include:Diarrhea, abdominal pain or cramps, dysmenorrhea, increased flatus, nausea, urinary urgency and frequency. For healthcare professionalsApplies to pyridostigmine: injectable solution, oral syrup, oral tablet, oral tablet extended release.Gastrointestinal adverse eventsFrequency not reported: Nausea, vomiting, diarrhea, abdominal cramps, GI hypermotility, salivary hypersecretion[Ref]RespiratoryFrequency not reported: Increased bronchial secretion combined with bronchoconstriction[Ref]MusculoskeletalFrequency not reported: Muscle weakness, fasciculation, tremors, muscle cramps, muscle hypotonia[Ref]OcularFrequency not reported: Miosis, increased lacrimation, accommodation disorders[Ref]DermatologicFrequency not reported:
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