Concurrent use of the anti-protozoal pyrimethamine may increase methotrexate may decrease the clearance of methotrexate causing elevated methotrexate.
Metotab 2.5 mg: one tablet contains 2.5 mg methotrexate (as methotrexate disodium). trimethoprim-sulfamethoxazole, chloramphenicol, pyrimethamine), attention
Pyrimethamine antifolate effect of methotrexate increased by pyrimethamine. Sulfamethoxazole increased risk of severe bone marrow depression (fatalities
methotrexate and/or its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. pyrimethamine), the risk of
Methotrexate (MTX) is used for the treatment of serious and refractory - Pyrimethamine. - Chloramphenicol. - Sulphonamides. - Cycloxygenase inhibitors.
by JH Goldie 2024 Cited by 21The effects of methotrexate and pyrimethamine were compared against methotrexate sensitive and resistant sublines of L5178Y lymphoblasts.
Pyrimethamine, An antiparasitic drug used in the prevention and treatment of Methotrexate, An antineoplastic agent used the treatment of a wide
Protonated state of methotrexate, trimethoprim, and pyrimethamine bound to dihydrofolate reductase List of references Publications that cite this publication.
Pyrimethamine, known chemically as 5-(4-chlorophenyl)-6-ethyl-2,4 methotrexate), while the patient is receiving pyrimethamine, may increase the
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