Purine analog drugs

Anti-Viral drugs. Many antiviral drugs are Purine or Pyrimidine analogs. Many antiviral drugs are Prodrugs. They must be phosphorylated by viral or

Study with Quizlet and memorize flashcards containing terms like antimetabolite chemotherapy drugs, purine analog chemotherapy drugs, cladribine and more.

Notably, the extent of these beneficial treatment effects was substantially greater than that achievable with purine analogs when compared with alkylator-based treatment (e.g. absolute improvement of PFS at five years of 20% for purine analog/cyclophosphamide combinations over purine analogs alone compared with an absolute PFS benefit at five

Valacyclovir is the L-valine ester of aciclovir. It is a member of the purine (guanine) nucleoside analog drug class. This class of drugs forms an

Historically, 6-mercaptopurine and 6-thioguanine, both purine analogs, were the first drugs to be used clinically for the treatment of leukemias . Another class of purine antimetabolites, the purine deoxynucleoside analogs fludarabine, cladribine, clofarabine, nelarabine, and pentostatin, are US Food and Drug Administration (FDA)-approved

Up to now, nucleoside analogs have been significant sources of antiviral and anticancer drugs [1,2,3], among which purine nucleoside analogs are widely used for the treatment of leukemia [4,5] and are also important precursors of several drugs [6,7]. To date, most purine nucleoside analogs are mainly synthesized by chemical methods [8,9,10].

Notably, the extent of these beneficial treatment effects was substantially greater than that achievable with purine analogs when compared with alkylator-based treatment (e.g. absolute improvement of PFS at five years of 20% for purine analog/cyclophosphamide combinations over purine analogs alone compared with an absolute PFS benefit at five

As anticancer drugs, nucleosides belong to a class of antimetabolites, a category that encompasses purine or pyrimidine analogs (nucleosides), folic acid and amino acid analogs, and ribonucleotide reductase inhibitors. [5]

Mechanism. purine analog. activated by HGPRTase. ↓ de novo purine synthesis ; Clinical use. leukemias. ALL. not CLL. lymphomas. not Hodgkin's.